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21:00 – Donnerstag 3 März, 2022
Real Betis – Rayo Vallecano
- Ausgestrahlt auf
- DAZN
Spielende (1 - 1)
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José Andrés Guardado Hernández Alejandro Moreno Lopera |  | 90' |
| 1-1 Borja Iglesias Quintas |  | 90' |
| 89' | | Kévin Manuel Rodrigues Álvaro García Rivera |
Borja Iglesias Quintas Willian José da Silva | | 86' |
Joaquín Sánchez Rodríguez Juan Miguel Jiménez López | | 82' |
| 80' | | 0-1 Tiago Manuel Dias Correia |
| Willian José da Silva |  | 79' |
| 77' | | Mamadou Sylla Diallo Sergio Guardiola Navarro |
| 77' | | Tiago Manuel Dias Correia Mario Suárez Mata |
| 71' | | Iván Balliu Campeny |
| 62' | | Santiago Comesaña Veiga Pathé Ciss |
| 61' | | Randy Ntekja Isaac Palazón Camacho |
| Halbzeitpause 0-0 | ||
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