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21:00 – Donnerstag 4 November, 2021
Bayer Leverkusen – Real Betis
- Ausgestrahlt auf
- RTL
Spielende (4 - 0)
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Kerem Demirbay Assists: Moussa Diaby |  | 90' |
| 90' | | Nabil Fekir |
| 4-0 Nadiem Amiri |  | 90' |
Odilon Kossounou Florian Wirtz |  | 88' |
Panagiotis Retsos Jeremie Frimpong | | 88' |
3-0 Florian Wirtz Assists: Moussa Diaby | | 86' |
| 79' | | Juan Miguel Jiménez López Joaquín Sánchez Rodríguez |
Daley Sinkgraven Piero Hincapie | | 77' |
Nadiem Amiri Amine Adli | | 77' |
| 71' | | Willian José da Silva Borja Iglesias Quintas |
Exequiel Palacios Paulo Henrique Sampaio Filho | | 68' |
| 60' | | Rodri Aitor Ruibal García |
| 2-0 Moussa Diaby | | 52' |
| Halbzeitpause 1-0 | ||
| 46' | | Sergio Canales Madrazo William Silva de Carvalho |
| 46' | | Alejandro Moreno Lopera Juan Miranda |
1-0 Moussa Diaby Assists: Florian Wirtz | | 42' |
| Amine Adli |  | 10' |
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